Cytoplasmic polyadenylation element
The cytoplasmic polyadenylation element (CPE) is a sequence element found in the 3' untranslated region of messenger RNA. While several sequence elements are known to regulate cytoplasmic polyadenylation, CPE is the best characterized. The most common CPE sequence is UUUUAU, though there are other variations. Binding of CPE binding protein (CPEB) to this region promotes the extension of the existing polyadenine tail and, in general, activation of the mRNA for protein … WebMar 30, 2024 · Further, as was the case with C12 RNA, Cl1 RNA contains a large masking element that prevents premature cytoplasmic polyadenylation during oocyte maturation. To examine the factors that may be involved in the cytoplasmic polyadenylation of both C12 and Cl1 RNAs, we performed UV cross-linking experiments in egg extracts.
Cytoplasmic polyadenylation element
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WebJun 14, 2013 · The cytoplasmic polyadenylation element (CPE) recruits its binding protein CPEB1. 96 This binding can be stabilized, especially on noncanonical CPEs, by … WebMar 31, 2024 · Critical regulatory elements that encode signals for transport, anchoring and translational regulation including signals for regulating cytoplasmic polyadenylation (cytoplasmic polyadenylation elements: CPE) are present in the 3′-untranslated region (3′UTR) of mRNA.
WebNov 19, 2024 · Cytoplasmic polyadenylation elements (CPEs) are located in the 3-prime UTRs of hundreds of mRNAs involved in cell proliferation, chromosome segregation, and cell differentiation. CPEs function as docking sites for CPE-binding proteins (CPEBs), which can either repress or activate mRNA translation. CPEB4 activates mRNA translation by … WebJun 12, 2013 · Introduction. The cytoplasmic polyadenylation element binding protein (CPEB) regulates the expression of proteins required for both early development and synaptic plasticity. 1 Previous studies on oogenesis and embryonic development have shown that translational regulation is required to establish polarity leading to cellular …
WebJun 14, 2013 · The cytoplasmic polyadenylation element (CPE) recruits its binding protein CPEB1. 96 This binding can be stabilized, especially on noncanonical CPEs, by the recruitment of Pumilio (PUM2) to the Pumilio binding element (PBE) and protein–protein interactions between CPEB1 and PUM2. 99, 121 CPEB1 in turn interacts with the … WebMar 2, 2009 · Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translation remains unclear. Control of poly(A) tail length by cytoplasmic polyadenylation element (CPE) binding protein 1 (CPEB1) is a …
WebThe cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific mRNA binding proteins that control translation in development, health, and disease. …
WebThe cytoplasmic polyadenylation element (CPE) is a nucleotide sequence within the 3′ UTR of mRNAs which binds to the CPE-binding protein (CPEB). A highly conserved … first year mom gifts+plansWebFunction. Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early … camping in sheridan wyWebCytoplasmic polyadenylation element-binding protein 1 Short names CPE-BP1; CPE-binding protein 1; mCPEB; mCPEB-1 Gene names Name Cpeb1 Synonyms Cpeb Organism names Organism Mus musculus (Mouse) Taxonomic … first year naval academy student is calledWebCytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB — a highly conserved, sequence-specific … camping in simi valley californiaWebJun 13, 2007 · CPEB1 binds to a short AU-rich sequence in responsive mRNAs called the cytoplasmic polyadenylation element (CPE) in the 3′ untranslated region (UTR). … camping inside grand canyonWebApr 23, 2004 · Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational … camping in sidmouth devonhttp://bioinformatics.louisville.edu/localresources/papers/CPEB-LNCS-Published.pdf first year mom gifts+systems