WitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul... Witryna5 maj 2008 · Inhibition of β-TrCP function sensitizes human ... (2001). C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. ... (2007). CRD-BP shields c-myc and ...
High-Throughput Fluorescence Anisotropy Screen for
WitrynaCRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper … Witryna20 cze 2024 · The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila. Mech. Dev. (2000) ... on the understanding of the oncogenic mechanism of CRD-BP as well as in the future design of inhibitors against CRD-BP function.Coding region determinant-binding protein (CRD-BP) interacts physically … birthday poem for women
CRD-BP Protects the Coding Region of βT - ScienceDirect
Witryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism … Witryna31 lip 2009 · Similarly, the half-life of a GBG mutant lacking an miR-183-binding site was not affected by CRD-BP, as compared to GBG containing the wild-type 577–1182 nt fragment of βTrCP1 (Figure 3 E). Knockdown of CRD-BP reduced expression of βTrCP1, but failed to do so when the function of miR-183 was inhibited (Figure 4 A). WitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … birthday poem for woman