WebApr 8, 2024 · Src homology 2 domain-containing inositol phosphate phosphatase 2 (SHIP2) is one of the 10 human inositol phosphate 5-phosphatases. One of its physiological … WebOct 19, 2011 · The widespread expression of SHIP2 suggests that inhibition of SHIP2 may find a broader clinical application, whereas the use of SHIP1 inhibitors may have the benefit of surpassing innocent bystander effects and therefore be more readily used in the treatment of hematological malignancies.
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WebMay 15, 2024 · SHIP2 is a 5′-lipid phosphatase, and acts as a negative regulator of PI3-kinase by hydrolyzing PI (3,4,5)P3 to PI (3,4)P 2 ( Sasaoka et al., 2006, Elong Edimo et al., 2013 ). Also, SHIP2 controls the nuclear PI (4,5)P 2 that locally regulates gene expression via protein kinase C ( Elong Edimo et al., 2013 ). WebOct 14, 2009 · In this study, the K m for Ins(1,3,4,5)P4 as substrate for SHIP2 was 44 ± 10 mM and Lineweaver–Burke analysis (Figure S1) indicated that AS1949490 was a competitive inhibitor, with a K i value estimated to be 0.44 µM for human SHIP2. To confirm the selectivity of AS1949490 for SHIP2, the inhibitory effect of AS1949490 was also …
Webphosphorylation inhibitor Applied Filters: Keyword: 'phosphorylation inhibitor' All Photos ( 1) RSK Inhibitor, SL0101 Synonym (s): RSK Inhibitor, SL0101 Empirical Formula (Hill Notation): C25H24O12 CAS No.: 77307-50-7 Molecular Weight: 516.45 Match Criteria: Keyword, Product Name All Photos ( 1) SRC N1 human Match Criteria: Keyword All Photos ( 1) Webvehicle or SHIP2 inhibitor AS1938909 (abbreviated as AS19) [32]. Twenty-four hours later, cells were stimu-lated with 1 mM H 2O 2 for 1 h. As a readout of PI3K and MAPK activation, AKT phosphorylation at Ser473 and ERK1/2 phosphorylation known to be Fig. 1. SHIP2 inhibition alters the PI3K and MAPK pathways upon H 2O 2 treatment. (A) Lysates ...
WebIn the present study, we have developed novel, potent SHIP2 inhibitors by extensive structural elaboration of crizotinib discovered from a high-throughput screening. Our representative compound 43 potently inhibited SHIP2 activity as well as GSK3β activation in HT22 neuronal cells. It was also shown that 43 has favorable physicochemical ... WebSHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease. For research use only. We do not sell to patients. SHIP2-IN-1 Chemical Structure CAS No. : 2252247-80-4 Get it March 20 by noon.
WebThe SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation …
WebOct 8, 2024 · Two types of small molecule inhibitors of SHP2 have recently emerged. SHP099 is an allosteric inhibitor of SHP2, and we have recently developed 11a-1, as an … polyedit 6 registration keyWebK149 (SHIP2 Inhibitor) SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI (3,4,5)P3 generating PI (3,4)P2. PI (3,4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. shanghai to buenos aires flightsWebAS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. shanghai to changsha flight timeWebinhibitors of PKB PH domain by virtual screening.15 We also identified earlier a synthetic biphenyl-derived polyphosphate, biphenyl 2,3′,4,5′,6-pentakisphosphate (BiPh-(2,3′,4,5′,6)P 5) (Figure 1 panel A), as a potent SHIP2 inhibitor.2 Here, we report the structure of the phosphatase domain of human SHIP2 (SHIP2-cd) in complex with poly edge e series phonesWebJan 15, 2024 · Several findings have pointed out a possible role of SHIP2 in apoptosis regulation. However, the molecular mechanisms behind remain unknown. Using embryonic fibroblast lacking the lipid 5′-phosphatase domain as a genetic model system and human liver cancer cells treated with SHIP2 inhibitor (AS1949490), as a pharmacological model … polyedro login teamsystempolyedro teamsystem manualeWebNov 30, 2016 · SHIP2 is a phosphatase that acts at the 5-position of phosphatidylinositol 3,4,5-trisphosphate. It is one of several enzymes that catalyse dephosphorylation at the … poly eedii firmware